Safe Compounding of
Hazardous Drugs Manual
Education Goals & Learning Objectives

The goal of this course is to educate supervisory and technical personnel involved in the Hazardous Drug Compounding process in both the theory and practices that assure the safety and efficacy of the IV products they compound and dispense, and the protection of operative personnel and the environment.

1. Hazardous Drugs

Upon completion of this section you should be able to:

• Understand how exposure to hazardous drug products can cause immediate injury and may
  present a long-term health risk.
• Understand how protection of product, personnel and the environment is achieved through an
  integrated system that incorporates Engineering Controls, Barrier Techniques, and Special
  Procedures.
• Understand the range of safe handling procedures that must be applied to all activities that
  involve handling hazardous drugs.

2.Engineering Controls

Upon completion of this section, you should be able to:

• Understand the design, limitations, and proper use of the Biological Safety Cabinet as a
  Primary Engineering Control when compounding hazardous drugs (a review).
• Understand the design, limitations, and proper use of Barrier Isolators.

3. Barrier Controls

Upon completion of this section, you should be able to:

• Understand the function, and don, use, and dispose of barrier controls effectively.

4. Special Procedures

Upon completion of this section you should be able to perform the following tasks:

• Select the correct syringes and tools for compounding, and understand their use.
• Reconstitute and compound product without aspiration of drug product using
  "Low-pressure" (See-Saw) technique.
• Perform all manipulations aseptically and safely.
• Perform containment manipulations using ampules.
• Recap syringes using one-handed technique.
• Maintain an accurate compounding log.
• Employ safe practices and proper hygiene.

5. Waste Disposal

Upon completion of this section you should be able to perform the following tasks:

• Identify proper disposal containers.
• Properly dispose of compounding wastes.

6. Receiving, Storage, Administration, and Transportation

Upon completion of this section you should be able to perform the following tasks:

• Receive and unpack drug shipments including hazardous drugs.
• Properly store hazardous drugs.
• Prepare drug products for administration and transport.

7. Spills, Exposures, and Injuries

Upon completion of this section you should be able to perform the following tasks:

• Proper clean-up of spills.
• Follow proper first-aid and follow-up medical procedures in the event of exposure or injury.
• Understand the OSHA Medical Surveillance and Hazard Communication Requirements
  that apply to Personnel Compounding Hazardous Drugs.